- Abstract:
-
The cystic fibrosis conductance regulator (CFTR) is a cAMP-regulated Cl(-) channel expressed predominantly at the apical membrane of secreting epithelial cells. Mutations in the CFTR gene lead to cystic fibrosis, the most frequent genetic disease in the Caucasian population. The most common mutation, a deletion of phenylalanine at position 508 (F508del), impairs CFTR folding and chloride channel function. Although an intense effort is under way to identify compounds that target the F508del CF...
Expand abstract - Publisher copy:
- 10.1111/bph.12017
-
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- Journal:
- British journal of pharmacology
- Volume:
- 169
- Issue:
- 1
- Pages:
- 1-9
- Publication date:
- 2013-05-05
- DOI:
- EISSN:
-
1476-5381
- ISSN:
-
0007-1188
- URN:
-
uuid:c39ec2cd-6f34-45c6-9eff-1385db714e48
- Source identifiers:
-
356286
- Local pid:
- pubs:356286
- Copyright date:
- 2013
Journal article
Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling.
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