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Journal article

Extracellular matrix-mediated chemotaxis can impede cell migration

Abstract:

Cells use a combination of changes in adhesion, proteolysis and motility (directed and random) during the process of migration. Proteolysis of the extracellular matrix (ECM) results in the creation of haptotactic gradients, which cells use to move in a directed fashion. The proteolytic creation of these gradients also results in the production of digested fragments of ECM. In this study we show that in the human fibrosarcoma cell line HT1080, matrix metallaproteinase-2 (MMP-2)-digested fragme...

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Publication status:
Published

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Publisher copy:
10.1098/rspb.1998.0582

Authors


Perumpanani, AJ More by this author
Simmons, DL More by this author
Gearing, AJH More by this author
Miller, KM More by this author
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Journal:
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume:
265
Issue:
1413
Pages:
2347-2352
Publication date:
1998-12-22
DOI:
EISSN:
1471-2970
ISSN:
0962-8452
URN:
uuid:c39bf676-b06e-4fdb-a73b-9801baab344b
Source identifiers:
18180
Local pid:
pubs:18180
Language:
English
Keywords:

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