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The influenza virus panhandle is involved in the initiation of transcription.

Abstract:

The role of the influenza A virus panhandle structure formed from the 3'- and 5'-terminal nucleotides of virion RNA segments was studied in both an RNA polymerase binding assay and an in vitro transcription assay. Despite recent indications that promoter activity is simply a function of the 3'-terminal sequence of virion RNA, our results show that both 3'- and 5'-terminal sequences are involved in the initiation of transcription. We propose a new model for the initiation of transcription whic...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of virology
Volume:
68
Issue:
6
Pages:
4092-4096
Publication date:
1994-06-05
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:c39bbc00-a3d9-4681-9881-f4bd2e444b30
Source identifiers:
6243
Local pid:
pubs:6243

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