Discrimination of benign from malignant prostatic disease by selective measurements of single chain, intact free prostate specific antigen.

Journal article

PURPOSE: Free prostate specific antigen (PSA) in serum consists of heterogeneous molecular subforms. Recently we developed an immunoassay for selective measurement of a subfraction of free PSA called intact PSA, which has been shown to be closely associated with prostate cancer. We assessed the ability of serum intact PSA to discriminate between benign and malignant prostatic disease. MATERIALS AND METHODS: In serum of 178 men with benign disease and 255 men with prostate cancer we measured ...

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Authors: Steuber, T; Nurmikko, P; Haese, A; Pettersson, K; Graefen, M

• Journal: Journal of urology
• Volume: 168
• Issue: 5
• Pages: 1917-1922
• Publication date: 2002-11-01
• DOI: 10.1097/00005392-200211000-00006
• EISSN: 1527-3792
• ISSN: 0022-5347
• Language: English
• Keywords: Protein Binding; Diagnosis, Differential; Prostatic Neoplasms; Male; Fluoroimmunoassay; Predictive Value of Tests; Biopsy; Reagent Kits, Diagnostic; Humans; Prostate; Tumor Markers, Biological; Reference Values; Prostatic Hyperplasia; Prostate-Specific Antigen