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NF-κB suppression by the deubiquitinating enzyme cezanne: A novel negative feedback loop in pro-inflammatory signaling

Abstract:

Transcription factors belonging to the NF-κB family regulate inflammation by inducing pro-inflammatory molecules (e.g. interleukin (IL)-8) in response to cytokines (e.g. tumor necrosis factor (TNF) α, IL-1) or other stimuli. Several negative regulators of NF-κB, including the ubiquitin-editing enzyme A20, participate in the resolution of inflammatory responses. We report that Cezanne, a member of the A20 family of the deubiquitinating cysteine proteases, can be induced by TNFα in cultured cel...

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Publisher copy:
10.1074/jbc.M708690200

Authors


Chaudhury, H More by this author
Rawlinson, L More by this author
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Journal:
Journal of Biological Chemistry
Volume:
283
Issue:
11
Pages:
7036-7045
Publication date:
2008-03-14
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:c38fb61a-4d96-4aa3-9232-3da149eb9182
Source identifiers:
225358
Local pid:
pubs:225358
Language:
English

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