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Journal article

Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease

Abstract:

BACKGROUND: The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. METHODS: Through DNA genotyping, we tested 54,003 coding-sequence variants covering 13,715 human genes in up to 72,868 patients with coronary artery disease and 120,770 controls who did not have coronary artery disease. Through DNA sequencing, we studied the effects of loss-of-function mutations in selected genes. RESULTS: We confi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1056/NEJMoa1507652

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Publisher:
Massachusetts Medical Society Publisher's website
Journal:
New England Journal of Medicine Journal website
Volume:
374
Issue:
12
Pages:
1134-1144
Publication date:
2016-03-24
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Source identifiers:
616102
Keywords:
Pubs id:
pubs:616102
UUID:
uuid:c384b0e8-0adb-4515-8e0a-7ee32e124be0
Local pid:
pubs:616102
Deposit date:
2016-06-03

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