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Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes.

Abstract:

Interaction of the T cell receptor (TCR) with peptide/major histocompatibility complexes (MHC) in the thymus is of critical importance for developing thymocytes. In a previous study, we described an antagonist peptide that inhibited negative selection of transgenic thymocytes induced by an agonist peptide. In this study we show that this antagonist peptide can induce positive selection of CD8(+) thymocytes more efficiently than the agonist or the weak agonist peptides, whereas the opposite is...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.95.14.8193

Authors


Williams, O More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
95
Issue:
14
Pages:
8193-8198
Publication date:
1998-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:c36affd8-dff6-4c58-9015-4df2cd21be86
Source identifiers:
20662
Local pid:
pubs:20662

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