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Species differences in the binding of compounds designed to fit a site of known structure in adult human haemoglobin.

Abstract:

1. Oxygen dissociation curves are reported for human haemoglobins A1, FII, FI, A1c and Raleigh (beta1 valine leads to acetylalanine) and for horse haemoglobin in the absence and presence of 2,3-diphosphoglycerate (DPG), or 4,4'-diformyl-2-bibenzyl oxyacetic acid, or the bisulphite addition compound of the latter. 2. These haemoglobins were selected because their amino acid sequences are different at the DPG receptor site of human adult deoxyhaemoglobin. 3. The size of the shifts of the dissoc...

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Publication status:
Published

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Journal:
British journal of pharmacology
Volume:
65
Issue:
3
Pages:
535-543
Publication date:
1979-03-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:c3653d16-67a2-4cee-a952-c244bdd70040
Source identifiers:
72668
Local pid:
pubs:72668

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