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Genome-wide association analysis identifies 27 novel loci associated with uterine leiomyomata revealing common genetic origins with endometriosis

Abstract:

Uterine leiomyomata (UL), also known as uterine fibroids, are the most common neoplasms of the reproductive tract and the primary cause for hysterectomy, leading to considerable impact on women's lives as well as high economic burden. Genetic epidemiologic studies indicate that heritable risk factors contribute to UL pathogenesis. Previous genome-wide association studies (GWAS) identified five loci associated with UL at genome-wide significance (P < 5 x 10-8). We conducted GWAS meta-analys...

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Publication status:
Not published
Peer review status:
Not peer reviewed

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Publisher copy:
10.1101/324905

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Contributors

Role:
Cold Spring Harbor Laboratory
National Institutes of Health More from this funder
Eunice Kennedy Shriver National Institute of Child Health and Human Development More from this funder
Journal:
biorxiv Journal website
Publication date:
2018-05-18
DOI:
Source identifiers:
891021
Pubs id:
pubs:891021
UUID:
uuid:c353f5b9-2360-4f2b-82a2-e2862ed39018
Local pid:
pubs:891021
Deposit date:
2018-09-13

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