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Argonaute2 mediates compensatory expansion of the pancreatic β cell

Abstract:

Pancreatic β cells adapt to compensate for increased metabolic demand during insulin resistance. Although the microRNA pathway has an essential role in β cell proliferation, the extent of its contribution is unclear. Here, we report that miR-184 is silenced in the pancreatic islets of insulin-resistant mouse models and type 2 diabetic human subjects. Reduction of miR-184 promotes the expression of its target Argonaute2 (Ago2), a component of the microRNA-induced silencing complex. Moreover, r...

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Publisher copy:
10.1016/j.cmet.2013.11.015

Authors


Tattikota, SG More by this author
Rathjen, T More by this author
McAnulty, SJ More by this author
Wessels, H-H More by this author
Akerman, I More by this author
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Journal:
Cell Metabolism
Volume:
19
Issue:
1
Pages:
122-134
Publication date:
2014-01-07
DOI:
EISSN:
1932-7420
ISSN:
1550-4131
URN:
uuid:c33e29a3-d43f-49f5-8587-9bd5c20d8d1c
Source identifiers:
447144
Local pid:
pubs:447144
Language:
English

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