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Evidence for reverse causality in the association between blood pressure and cardiovascular risk in patients with chronic kidney disease

Abstract:

Among those with moderate-to-advanced chronic kidney disease, the relationship between blood pressure and cardiovascular disease appears ‘U’-shaped, but is loglinear in apparently healthy adults. The Study of Heart and Renal Protection randomized 9270 patients with chronic kidney disease to simvastatin/ezetimbe versus matching placebo, and measured blood pressure at each follow-up visit. Cox regression was used to assess the association between blood pressure and risk of cardiovascular diseas...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1161/HYPERTENSIONAHA.116.08386

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Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
More by this author
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
More by this author
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
More by this author
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
More by this author
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
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Merck & Co. More from this funder
Australian National Health Medical Research Council More from this funder
British Heart Foundation More from this funder
Medical Research Council More from this funder
Publisher:
American Heart Association Publisher's website
Journal:
Hypertension Journal website
Volume:
2017
Issue:
69
Pages:
314-322
Publication date:
2016-12-27
Acceptance date:
2016-11-08
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Pubs id:
pubs:661559
URN:
uri:c30fd5d3-73e4-4cda-b437-88ce1b03cd9a
UUID:
uuid:c30fd5d3-73e4-4cda-b437-88ce1b03cd9a
Local pid:
pubs:661559
Paper number:
69

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