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Mesoangioblasts suppress T cell proliferation through IDO and PGE-2-dependent pathways.

Abstract:

Human mesoangioblasts are vessel-associated stem cells that are currently in phase I/II clinical trials for the treatment of patients with Duchenne muscular dystrophy. To date, little is known about the effect of mesoangioblasts on human immune cells and vice versa. We hypothesized that mesoangioblasts could modulate the function of immune cells in a similar manner to mesenchymal stromal cells. Human mesoangioblasts did not evoke, but rather potently suppressed human T-cell proliferation and ...

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Publication status:
Published

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Publisher copy:
10.1089/scd.2012.0386

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
Stem Cells Dev
Volume:
22
Issue:
3
Pages:
512-523
Publication date:
2013-02-01
DOI:
EISSN:
1557-8534
ISSN:
0019-2805
Source identifiers:
354032

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