Beta-Interferon treatment does not always slow the progression of axonal injury in multiple sclerosis.

Journal article

Progression of disability in multiple sclerosis (MS) appears related to axonal damage, which is at least in part associated with white matter lesions. Beta-interferon (BIFN) substantially reduces new inflammatory activity in MS and a recent report suggested that it may reverse a component of axonal injury. To test the generalisability of this conclusion, particularly in a population with relatively active disease, we used magnetic resonance spectroscopy measures to test whether BIFN can rever...

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Authors: Parry, A; Corkill, R; Blamire, A; Palace, J; Narayanan, S

• Publication status: Published
• Journal: Journal of neurology
• Volume: 250
• Issue: 2
• Pages: 171-178
• Publication date: 2003-02-01
• DOI: 10.1007/s00415-003-0965-8
• EISSN: 1432-1459
• ISSN: 0340-5354
• Language: English
• Keywords: Creatine; Longitudinal Studies; Humans; Magnetic Resonance Spectroscopy; Recurrence; Brain Chemistry; Female; Disease Progression; Male; Multiple Sclerosis; Aspartic Acid; Axons; Interferon Type I, Recombinant; Cohort Studies; Adult; Magnetic Resonance Imaging; Body Water