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Androgen manipulation alters oxidative DNA adduct levels in androgen-sensitive prostate cancer cells grown in vitro and in vivo.

Abstract:

Intracellular reactive oxygen species (ROS) may cause oxidative DNA damage, resulting in the formation of adducts such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) and the cyclic pyrimidopurinone N-1, N(2) malondialdehyde-2'-deoxyguanosine (M(1)dG). These adducts have been associated with carcinogenesis, genomic instability and clonal evolution. We tested two hypotheses in human prostate cancer cells grown in vitro and in a xenograft model: (1) treatment of androgen-sensitive cells with ...

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Publication status:
Published

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Journal:
Cancer letters
Volume:
261
Issue:
1
Pages:
74-83
Publication date:
2008-03-05
DOI:
EISSN:
1872-7980
ISSN:
0304-3835
URN:
uuid:c2ebef9a-87b6-45f6-8db3-cda6d815517a
Source identifiers:
132037
Local pid:
pubs:132037

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