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Journal article

Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure.

Abstract:

BACKGROUND: The candidate malaria vaccine RTS,S/AS01E has entered phase 3 trials, but data on long-term outcomes are limited. METHODS: For 4 years, we followed children who had been randomly assigned, at 5 to 17 months of age, to receive three doses of RTS,S/AS01E vaccine (223 children) or rabies vaccine (224 controls). The end point was clinical malaria (temperature of ≥37.5°C and Plasmodium falciparum parasitemia density of >2500 parasites per cubic millimeter). Each child's exposure to ...

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Publication status:
Published

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Publisher copy:
10.1056/NEJMoa1207564

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
Nyangweso, G More by this author
Awuondo, KO More by this author
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Journal:
The New England journal of medicine
Volume:
368
Issue:
12
Pages:
1111-1120
Publication date:
2013-03-05
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
URN:
uuid:c2db2af1-bf4f-41e3-be1e-677bfba5c49d
Source identifiers:
390827
Local pid:
pubs:390827

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