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Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta-cells.

Abstract:

1. We have investigated the mechanism by which L-arginine stimulates membrane depolarization, an increase of intracellular calcium ([Ca2+]i) and insulin secretion in pancreatic beta-cells. 2. L-Arginine failed to affect beta-cell metabolism, as monitored by NAD(P)H autofluorescence. 3. L-Arginine produced a dose-dependent increase in [Ca2+]i, which was dependent on membrane depolarization and extracellular calcium. 4. The cationic amino acids L-ornithine, L-lysine, L-homoarginine (which is no...

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Publication status:
Published

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Journal:
The Journal of physiology
Volume:
499 ( Pt 3)
Issue:
3
Pages:
625-635
Publication date:
1997-03-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:c2ce4656-29dc-47eb-a218-7006e6ffc814
Source identifiers:
113446
Local pid:
pubs:113446

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