Journal article
Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta-cells.
- Abstract:
-
1. We have investigated the mechanism by which L-arginine stimulates membrane depolarization, an increase of intracellular calcium ([Ca2+]i) and insulin secretion in pancreatic beta-cells. 2. L-Arginine failed to affect beta-cell metabolism, as monitored by NAD(P)H autofluorescence. 3. L-Arginine produced a dose-dependent increase in [Ca2+]i, which was dependent on membrane depolarization and extracellular calcium. 4. The cationic amino acids L-ornithine, L-lysine, L-homoarginine (which is no...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Journal of physiology More from this journal
- Volume:
- 499 ( Pt 3)
- Issue:
- 3
- Pages:
- 625-635
- Publication date:
- 1997-03-01
- DOI:
- EISSN:
-
1469-7793
- ISSN:
-
0022-3751
Item Description
- Language:
-
English
- Keywords:
-
- Pubs id:
-
pubs:113446
- UUID:
-
uuid:c2ce4656-29dc-47eb-a218-7006e6ffc814
- Local pid:
-
pubs:113446
- Source identifiers:
-
113446
- Deposit date:
-
2012-12-19
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- Copyright date:
- 1997
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