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Detection of microglial activation in an acute model of neuroinflammation using PET and radiotracers 11C-(R)-PK11195 and 18F-GE-180.

Abstract:

UNLABELLED: It remains unclear how different translocator protein (TSPO) ligands reflect the spatial extent of astrocyte or microglial activation in various neuroinflammatory conditions. Here, we use a reproducible lipopolysaccharide (LPS)-induced model of acute central nervous system inflammation to compare the binding performance of a new TSPO ligand (18)F-GE-180 with (11)C-(R)-PK11195. Using immunohistochemistry, we also explore the ability of the TSPO ligands to detect activated microglia...

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Publication status:
Published

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Publisher copy:
10.2967/jnumed.113.125625

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Journal:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume:
55
Issue:
3
Pages:
466-472
Publication date:
2014-03-01
DOI:
EISSN:
1535-5667
ISSN:
0161-5505
Source identifiers:
458571
Language:
English
Keywords:
Pubs id:
pubs:458571
UUID:
uuid:c2cc1ada-ce0d-4fc1-a073-8af3872f5c23
Local pid:
pubs:458571
Deposit date:
2014-06-30

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