We present a model for tumour metabolism that incorporates both microenvironmental (extracellular) and oncogenic (intracellular) influences. We explore the effects of the interaction between the hypoxic microenvironment and intracellular signalling on the glycolytic response of tumour tissue, finding that the glycolytic state is dependent on a delicately balanced interplay between the cellular hypoxic response, mediated by hypoxia-inducible factor-1alpha (HIF-1alpha), and growth-factor signal...Expand abstract
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Tumour glycolysis: the many faces of HIF.
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