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Tumour glycolysis: the many faces of HIF.

Abstract:

We present a model for tumour metabolism that incorporates both microenvironmental (extracellular) and oncogenic (intracellular) influences. We explore the effects of the interaction between the hypoxic microenvironment and intracellular signalling on the glycolytic response of tumour tissue, finding that the glycolytic state is dependent on a delicately balanced interplay between the cellular hypoxic response, mediated by hypoxia-inducible factor-1alpha (HIF-1alpha), and growth-factor signal...

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Publication status:
Published

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Publisher copy:
10.1016/j.jtbi.2008.05.025

Authors


Journal:
Journal of theoretical biology
Volume:
254
Issue:
2
Pages:
508-513
Publication date:
2008-09-05
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
URN:
uuid:c2cb292b-e67f-4e2c-bfd0-dad5c1f4a46a
Source identifiers:
64918
Local pid:
pubs:64918

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