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Genetic association analysis reveals differences in the contribution of NOD2 variants to the clinical phenotypes of orofacial granulomatosis

Abstract:

Background

Orofacial granulomatosis (OFG) is a rare, inflammatory disorder of the mouth, in which some patients also have intestinal Crohn’s disease (CD). The etiology remains largely unknown, although there is a high prevalence of atopy, and oral granulomas are also seen in other immune disorders particularly CD and sarcoidosis. We investigated whether genetic variants associated with an increased risk of CD, sarcoidosis, or atopy were also associated with susceptibility to OFG....

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1097/MIB.0000000000000844

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Oxford college:
Keble College
ORCID:
0000-0002-4502-2209
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National Institute for Health Research More from this funder
Isaac Schapera Trust Fund More from this funder
Friends of Guy’s Hospital More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Inflammatory Bowel Diseases Journal website
Volume:
22
Issue:
7
Pages:
1552-1558
Publication date:
2016-06-10
Acceptance date:
2016-04-05
DOI:
EISSN:
1536-4844
ISSN:
1078-0998
Pubs id:
pubs:632739
URN:
uri:c2b8a179-d005-4aa7-b3f3-6518156f39af
UUID:
uuid:c2b8a179-d005-4aa7-b3f3-6518156f39af
Local pid:
pubs:632739

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