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The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48.

Abstract:

Mast cells are well known for their harmful role in IgE-mediated hypersensitivity reactions, but their physiological role remains a mystery. Several recent studies have reported that mast cells play a critical role in innate immunity in mice by releasing tumor necrosis factor alpha (TNF-alpha) to recruit neutrophils to sites of enterobacterial infection. In some cases, the mast cell TNF-alpha response was triggered when these cells directly bound FimH on the surface of Escherichia coli. We ha...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.96.14.8110

Authors


Malaviya, R More by this author
Thankavel, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Abraham, SN More by this author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
96
Issue:
14
Pages:
8110-8115
Publication date:
1999-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:c2af9c10-f429-46bc-b05d-e236c31339a9
Source identifiers:
31103
Local pid:
pubs:31103

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