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Abnormal Cell Surface Antigen Expression in Individuals with Variant CD45 Splicing and Histiocytosis

Abstract:

Hemophagocytic lymphohistiocytosis (HLH) and Langerhans cell histiocytosis (LCH) are members of a group of rare heterogenous disorders, the histiocytoses, characterized by uncontrolled accumulation of pleomorphic infiltrates of leukocytes. The etiology of these diseases is mainly unknown. CD45 is a hemopoietic cell specific tyrosine phosphatase essential for antigen receptor mediated signaling in lymphocytes and different patterns of CD45 splicing are associated with distinct functions. Recen...

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Journal:
Pediatric Research
Volume:
55
Issue:
3
Pages:
478-484
Publication date:
2004-03-05
DOI:
ISSN:
0031-3998
URN:
uuid:c2a77638-1e00-4595-abbf-ca603d0f0a4d
Source identifiers:
176576
Local pid:
pubs:176576
Language:
English

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