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Journal article

Use of weighted multivariate estimates in trials of multi-serotype vaccines to simplify interpretation of treatment differences

Abstract:

BACKGROUND: Many vaccines contain multiple components. Licensed pneumococcal conjugate vaccines (PCV) contain polysaccharides from 7, 10, or 13 different serotypes of Streptococcus pneumoniae. The main outcomes in randomised trials of pneumococcal vaccines are serotype-specific antibody measures. Comparisons are made between groups for each serotype, resulting in multiple separate comparisons of treatment effects which can be complicated to interpret. We investigated methods for computing the...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0196200

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care; Primary Care Health Sciences
Oxford college:
All Souls College
ORCID:
0000-0001-6324-6559
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care; Primary Care Health Sciences
Shrestha, S More by this author
Thorson, S More by this author
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Grant:
Doctoral Research Fellowship DRF-2015-08-048
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
13
Issue:
4
Pages:
e0196200
Publication date:
2018-07-27
Acceptance date:
2018-04-07
DOI:
EISSN:
1932-6203
Pubs id:
pubs:844807
URN:
uri:c2a1d5d3-c1bf-44bd-9766-d36c85ae3bff
UUID:
uuid:c2a1d5d3-c1bf-44bd-9766-d36c85ae3bff
Local pid:
pubs:844807

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