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Journal article

The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives.

Abstract:
We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.1031527100

Authors


Pavlović, D More by this author
Neville, DCA More by this author
Blumberg, B More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of the United States of America Journal website
Volume:
100
Issue:
10
Pages:
6104-6108
Publication date:
2003-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:c2a05af2-875f-4604-95f9-0ac92f6a93ce
Source identifiers:
100005
Local pid:
pubs:100005

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