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A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor

Abstract:

The inactivation of BRCA2, a suppressor of breast, ovarian and other epithelial cancers, triggers instability in chromosome structure and number, which are thought to arise from defects in DNA recombination and mitotic cell division, respectively. Human BRCA2 controls DNA recombination via eight BRC repeats, evolutionarily conserved motifs of 35 residues, that interact directly with the recombinase RAD51. How BRCA2 controls mitotic cell division is debated. Several studies by different groups...

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Publisher copy:
10.1038/onc.2011.55

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Journal:
Oncogene
Volume:
30
Issue:
30
Pages:
3360-3369
Publication date:
2011-07-28
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
Source identifiers:
172458
Language:
English
Keywords:
Pubs id:
pubs:172458
UUID:
uuid:c2839e97-1a77-47ff-8cf5-79158120fa73
Local pid:
pubs:172458
Deposit date:
2012-12-19

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