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hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to establish polycomb-mediated chromosomal silencing

Abstract:

The Polycomb-repressive complexes PRC1 and PRC2 play a key role in chromosome silencing induced by the non-coding RNA Xist. Polycomb recruitment is initiated by the PCGF3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine 119 ubiquitylation, signaling recruitment of other PRC1 complexes, and PRC2. However, the molecular mechanism for PCGF3/5-PRC1 recruitment by Xist RNA is not understood. Here we define the Xist RNA Polycomb Interaction Domain (XR-PID), a 600 nt sequence encompassing ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.molcel.2017.11.013

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Grant:
103768; 091911; 099682
Publisher:
Cell Press Publisher's website
Journal:
Molecular Cell Journal website
Volume:
68
Issue:
5
Pages:
955-969.e10
Publication date:
2017-12-07
Acceptance date:
2017-11-10
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Pubs id:
pubs:810680
URN:
uri:c27d29aa-e0ca-494a-953f-cab426b23236
UUID:
uuid:c27d29aa-e0ca-494a-953f-cab426b23236
Local pid:
pubs:810680
Paper number:
5
Language:
English
Keywords:

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