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SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

Abstract:

Background Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving limited insights into mucosal defences that prevent viral replication and onward transmission. We studied nasal and plasma antibody responses one year after hospitalisation for COVID-19, including a period when SARS-CoV-2 vaccination was introduced.

Methods In this follow up study, plasma and nasosorption samples were prospectively collected from 446 adults hosp...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ebiom.2022.104402

Authors


Contributors

Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
ISARIC4C; PHOSP-COVID
Role:
Contributor
Publisher:
Elsevier
Journal:
EBioMedicine More from this journal
Volume:
87
Article number:
104402
Place of publication:
Netherlands
Publication date:
2022-12-19
Acceptance date:
2022-11-22
DOI:
EISSN:
2352-3964
Pmid:
36543718
Language:
English
Keywords:
Pubs id:
1316850
Local pid:
pubs:1316850
Deposit date:
2023-01-20

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