Journal article icon

Journal article

The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study.

Abstract:

BACKGROUND: A major event in the post-meiotic development of male germ cells is the formation of the acrosome. This process can be perturbed in C57BL/6 mice by administration of the small molecule miglustat (N-butyldeoxynojirimycin, NB-DNJ). The miglustat-treated mice produce morphologically abnormal spermatozoa that lack acrosomes and are poorly motile. In C57BL/6 mice, miglustat can be used to maintain long-term reversible infertility. In contrast, when miglustat was evaluated in normal me...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1186/1477-7827-5-1

Authors


Expand authors...
Journal:
Reproductive biology and endocrinology : RBandE
Volume:
5
Pages:
1
Publication date:
2007-01-01
DOI:
EISSN:
1477-7827
ISSN:
1477-7827
URN:
uuid:c27a5ca5-ad8e-4991-a9f6-5ab1d9839cb8
Source identifiers:
185130
Local pid:
pubs:185130

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP