Nicotinic acid adenine dinucleotide phosphate mediates Ca2+ signals and contraction in arterial smooth muscle via a two-pool mechanism.

Journal article

Previous studies of arterial smooth muscle have shown that inositol 1,4,5-trisphosphate (IP3) and cyclic ADP-ribose mobilize Ca2+ from the sarcoplasmic reticulum. In contrast, little is known about Ca2+ mobilization by nicotinic acid adenine dinucleotide phosphate, a pyridine nucleotide derived from beta-NADP+. We show here that intracellular dialysis of nicotinic acid adenine dinucleotide phosphate (NAADP) induces spatially restricted "bursts" of Ca2+ release that initiate a global Ca2+ wave...

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Authors: Boittin, F; Galione, A; Evans, A

• Publication status: Published
• Journal: Circulation research
• Volume: 91
• Issue: 12
• Pages: 1168-1175
• Publication date: 2002-12-01
• DOI: 10.1161/01.res.0000047507.22487.85
• EISSN: 1524-4571
• ISSN: 0009-7330
• Language: English
• Keywords: Rats, Wistar; Animals; Receptors, Cytoplasmic and Nuclear; Inositol 1,4,5-Trisphosphate Receptors; Rats; Muscle, Smooth, Vascular; Calcium Channels; Oxazoles; Calcium Signaling; Vasoconstriction; Macrocyclic Compounds; Ryanodine; Cell Separation; Pulmonary Artery; Male; Cell Compartmentation; Dose-Response Relationship, Drug; Calcium; Second Messenger Systems; Microdialysis; Sarcoplasmic Reticulum; NADP; Patch-Clamp Techniques; Enzyme Inhibitors