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Repair of tandem base lesions in DNA by human cell extracts generates persisting single-strand breaks.

Abstract:

Clustered DNA damage, where two or more lesions are located proximal to each other on the same or opposite DNA strands, is frequently produced as a result of exposure to ionising radiation. It has been suggested that such complex damaged sites pose problems for repair pathways. In this study, we addressed the question of how two 8-oxoguanine lesions, located two nucleotides apart on the same DNA strand, are repaired. We find that in human cell extracts repair of either of the 8-oxoguanine les...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2005.06.069

Authors


Budworth, H More by this author
Matthewman, G More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Journal of molecular biology
Volume:
351
Issue:
5
Pages:
1020-1029
Publication date:
2005-09-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:c26478a1-0d96-4d80-911e-8fb24bda8fec
Source identifiers:
131224
Local pid:
pubs:131224

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