- Abstract:
- Self-assembling proteins, the basis for a broad range of biological scaffolds, are challenging to study using most structural biology approaches. Here we show that mass spectrometry (MS) in combination with MD simulations captures structural features of short-lived oligomeric intermediates in spider silk formation, providing direct insights into its complex assembly process.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.0MB)
-
- Publisher copy:
- 10.1039/c7cc00307b
-
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- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Chemical Communications Journal website
- Volume:
- 53
- Pages:
- 3319-3322
- Publication date:
- 2017-02-05
- Acceptance date:
- 2017-02-01
- DOI:
- ISSN:
-
1364-548X
- Pubs id:
-
pubs:681694
- URN:
-
uri:c2556b66-4ac0-4930-a7c3-a5515c67852b
- UUID:
-
uuid:c2556b66-4ac0-4930-a7c3-a5515c67852b
- Local pid:
- pubs:681694
- Language:
- English
- Keywords:
- Copyright holder:
- Royal Society of Chemistry
- Copyright date:
- 2017
- Notes:
- © The Royal Society of Chemistry 2017. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Journal article
Mass spectrometry captures structural intermediates in protein fiber self-assembly.
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