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Mass spectrometry captures structural intermediates in protein fiber self-assembly.

Abstract:
Self-assembling proteins, the basis for a broad range of biological scaffolds, are challenging to study using most structural biology approaches. Here we show that mass spectrometry (MS) in combination with MD simulations captures structural features of short-lived oligomeric intermediates in spider silk formation, providing direct insights into its complex assembly process.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/c7cc00307b

Authors


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Grant:
Marie Curie Early Career Development Grant
Karolinska Institutet More from this funder
Stockholm City Council More from this funder
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Funding agency for:
Robinson, C
Grant:
MR/N020413/1
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Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Chemical Communications Journal website
Volume:
53
Pages:
3319-3322
Publication date:
2017-02-01
Acceptance date:
2017-02-01
DOI:
ISSN:
1364-548X
Source identifiers:
681694
Language:
English
Keywords:
Pubs id:
pubs:681694
UUID:
uuid:c2556b66-4ac0-4930-a7c3-a5515c67852b
Local pid:
pubs:681694
Deposit date:
2017-03-07

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