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Novel Plasmodium vivax dhfr alleles from the Indonesian Archipelago and Papua New Guinea: association with pyrimethamine resistance determined by a Saccharomyces cerevisiae expression system.

Abstract:

In plasmodia, the dihydrofolate reductase (DHFR) enzyme is the target of the pyrimethamine component of sulfadoxine-pyrimethamine (S/P). Plasmodium vivax infections are not treated intentionally with antifolates. However, outside Africa, coinfections with Plasmodium falciparum and P. vivax are common, and P. vivax infections are often exposed to S/P. Cloning of the P. vivax dhfr gene has allowed molecular comparisons of dhfr alleles from different regions. Examination of the dhfr locus from a...

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Publication status:
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Authors


Hastings, MD More by this author
Maguire, JD More by this author
Zimmerman, PA More by this author
Reeder, JC More by this author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
49
Issue:
2
Pages:
733-740
Publication date:
2005-02-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:c2301d30-3ef7-4ca7-a60a-fdab06a46c8d
Source identifiers:
81705
Local pid:
pubs:81705

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