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Journal article

The requirement for potent adjuvants to enhance the immunogenicity and protective efficacy of protein vaccines can be overcome by prior immunization with a recombinant adenovirus.

Abstract:

A central goal in vaccinology is the induction of high and sustained Ab responses. Protein-in-adjuvant formulations are commonly used to achieve such responses. However, their clinical development can be limited by the reactogenicity of some of the most potent preclinical adjuvants and the cost and complexity of licensing new adjuvants for human use. Also, few adjuvants induce strong cellular immunity, which is important for protection against many diseases, such as malaria. We compared class...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1101004

Authors


de Cassan, SC More by this author
Forbes, EK More by this author
Douglas, AD More by this author
Milicic, A More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
187
Issue:
5
Pages:
2602-2616
Publication date:
2011-09-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:c22f204f-a369-49f6-b325-3d929237525c
Source identifiers:
167589
Local pid:
pubs:167589

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