- Abstract:
-
Previous studies have shown that expression of the immune co-stimulator B7.1 reduces the tumorigenicity of some, but not all, malignant cell lines. However, B7.1-expressing tumor cells are not very effective in inducing the rejection of established tumors. This may in part be due to induction of anergy in the potentially reactive T cells. Previous studies have shown that IL-2 can reverse the anergic state both in vitro and in vivo. Therefore, we have examined the effect of retrovirus-mediated...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1089/hum.1997.8.4-477
-
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- Journal:
- Human gene therapy
- Volume:
- 8
- Issue:
- 4
- Pages:
- 477-488
- Publication date:
- 1997-03-05
- DOI:
- EISSN:
-
1557-7422
- ISSN:
-
1043-0342
- URN:
-
uuid:c22e7f2a-0feb-45e1-a3ce-1cfb50cc681f
- Source identifiers:
-
466397
- Local pid:
- pubs:466397
- Language:
- English
- Keywords:
- Copyright date:
- 1997
Journal article
Irradiated NC adenocarcinoma cells transduced with both B7.1 and interleukin-2 induce CD4+-mediated rejection of established tumors.
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