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Journal article

Irradiated NC adenocarcinoma cells transduced with both B7.1 and interleukin-2 induce CD4+-mediated rejection of established tumors.

Abstract:

Previous studies have shown that expression of the immune co-stimulator B7.1 reduces the tumorigenicity of some, but not all, malignant cell lines. However, B7.1-expressing tumor cells are not very effective in inducing the rejection of established tumors. This may in part be due to induction of anergy in the potentially reactive T cells. Previous studies have shown that IL-2 can reverse the anergic state both in vitro and in vivo. Therefore, we have examined the effect of retrovirus-mediated...

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Publication status:
Published

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Publisher copy:
10.1089/hum.1997.8.4-477

Authors


Hollingsworth, SJ More by this author
Buggins, AG More by this author
Galea-Lauri, J More by this author
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Journal:
Human gene therapy
Volume:
8
Issue:
4
Pages:
477-488
Publication date:
1997-03-05
DOI:
EISSN:
1557-7422
ISSN:
1043-0342
URN:
uuid:c22e7f2a-0feb-45e1-a3ce-1cfb50cc681f
Source identifiers:
466397
Local pid:
pubs:466397

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