Selective imaging of the angiogenic relevant integrins α5β1 and αvβ3.

Journal article

Pattern seekers: For the two angiogenic relevant integrins α5β1 and αvβ3, functionalized derivatives of the selective antagonists 1 and 2 could target and discriminate between tumor cells in vivo based on their different integrin patterns and also delay tumor growth in vivo. In addition, the first α5β1-selective integrin antagonist that enables specific molecular imaging by positron emission tomography was developed.

Authors: Neubauer, S; Rechenmacher, F; Beer, A; Curnis, F; Pohle, K

• Journal: Angewandte Chemie (International ed. in English)
• Volume: 52
• Issue: 44
• Pages: 11656-11659
• Publication date: 2013-10-01
• DOI: 10.1002/anie.201306376
• EISSN: 1521-3773
• ISSN: 1433-7851
• Language: English
• Keywords: Integrin alpha5beta1; Angiogenesis Modulating Agents; Humans; Mice; Positron-Emission Tomography; Animals; Peptidomimetics; Integrin alphaVbeta3; Rats