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Key role for clumping factor B in Staphylococcus aureus nasal colonization of humans.

Abstract:

BACKGROUND: Staphylococcus aureus permanently colonizes the vestibulum nasi of one-fifth of the human population, which is a risk factor for autoinfection. The precise mechanisms whereby S. aureus colonizes the nose are still unknown. The staphylococcal cell-wall protein clumping factor B (ClfB) promotes adhesion to squamous epithelial cells in vitro and might be a physiologically relevant colonization factor. METHODS AND FINDINGS: We define the role of the staphylococcal cytokeratin-binding...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.0050017

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Choudhurry, R More by this author
Melles, DC More by this author
Boelens, HA More by this author
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Grant:
97030.14/04.0687/pme
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
5
Issue:
1
Pages:
Article: e17
Publication date:
2008-01-05
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:c2160858-a2d8-457d-808e-d42e07b1923a
Source identifiers:
95187
Local pid:
pubs:95187

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