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Investigating the efficacy of triple artemisinin-based combination therapies (TACTs) for treating Plasmodium falciparum malaria patients using mathematical modelling

Abstract:

The first line treatment for uncomplicated falciparum malaria is artemisinin-based combination therapy (ACT), which consists of an artemisinin derivative co-administered with a longer acting partner drug. However, the spread of Plasmodium falciparum resistant to both artemisinin and its partner drugs poses a major global threat to malaria control activities. Novel strategies are needed to retard and reverse the spread of these resistant parasites. One such strategy is triple artemisinin-based...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/aac.01068-18

Authors


Zaloumis, S More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
ORCID:
0000-0003-2000-2874
Fowkes, FJI More by this author
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Funding agency for:
Price, RN
Australian National Health and Medical Research Council More from this funder
Australian Research Council More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
62
Issue:
11
Pages:
e01068-18
Publication date:
2018-08-27
Acceptance date:
2018-08-27
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pubs id:
pubs:911978
URN:
uri:c208b91d-8ac1-4fb0-80cf-9cc188f28ac7
UUID:
uuid:c208b91d-8ac1-4fb0-80cf-9cc188f28ac7
Local pid:
pubs:911978
Language:
English
Keywords:

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