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Dopamine, Salience, and Response Set Shifting in Prefrontal Cortex.

Abstract:

Dopamine is implicated in multiple functions, including motor execution, action learning for hedonically salient outcomes, maintenance, and switching of behavioral response set. Here, we used a novel within-subject psychopharmacological and combined functional neuroimaging paradigm, investigating the interaction between hedonic salience, dopamine, and response set shifting, distinct from effects on action learning or motor execution. We asked whether behavioral performance in response set shi...

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Publisher copy:
10.1093/cercor/bhu210

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Guitart-Masip, M More by this author
Fleming, SM More by this author
Friston, KJ More by this author
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Journal:
Cerebral cortex (New York, N.Y. : 1991)
Publication date:
2014-09-05
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
URN:
uuid:c200f26f-4e5d-4b73-ba02-d3b2dab63bec
Source identifiers:
485228
Local pid:
pubs:485228

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