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MICA expression is regulated by cell adhesion and contact in a FAK/Src-dependent manner

Abstract:

MICA is a major ligand for the NKG2D immune receptor, which plays a key role in activating natural killer (NK) cells and cytotoxic T cells. We analyzed NKG2D ligand expression on a range of cell types and could demonstrate that MICA expression levels were closely linked to cellular growth mode. While the expression of other NKG2D ligands was largely independent of cell growth mode, MICA expression was mainly found on cells cultured as adherent cells. In addition, MICA surface expression was r...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2016.00687

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; CCMP
Role:
Author
More by this author
Role:
Author
ORCID:
0000-0001-7148-7096
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; CCMP
Oxford college:
Queens College
Role:
Author
Secretaría Nacional de Ciencia, Tecnología e Innovación More from this funder
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
7
Issue:
JAN
Pages:
Article: 687
Publication date:
2017-01-19
Acceptance date:
2016-12-23
DOI:
ISSN:
1664-3224
Pubs id:
pubs:679719
URN:
uri:c1fad6ac-3ba5-4ee9-8d11-d46021e67d0c
UUID:
uuid:c1fad6ac-3ba5-4ee9-8d11-d46021e67d0c
Local pid:
pubs:679719
Language:
English
Keywords:

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