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Journal article

Human antibody pieces together the puzzle of the trimeric Lassa virus surface antigen

Abstract:
The envelope glycoprotein spike, the sole antigen on the Lassa virus (LASV) surface, constitutes the focal point of the host neutralizing immune response. A high-resolution structure of the trimeric LASV glycoprotein in an antibody-bound form illuminates the molecular architecture of the antigen and reveals the mode of action of the most abundant known class of Lassa-specific human neutralizing antibodies.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nsmb.3431

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More from this funder
Funding agency for:
Zeltina, A
Grant:
MR/N002091/1
More from this funder
Funding agency for:
Bowden, T
Grant:
MR/N002091/1
Publisher:
Springer Nature Publisher's website
Journal:
Nature Structural and Molecular Biology Journal website
Volume:
24
Issue:
7
Pages:
559-560
Publication date:
2017-07-06
Acceptance date:
2017-06-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Source identifiers:
707583
Language:
English
Subjects:
Pubs id:
pubs:707583
UUID:
uuid:c1fa492e-77d0-4a67-8b7b-5ba5aa3a5022
Local pid:
pubs:707583
Deposit date:
2017-07-20

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