- Abstract:
- The envelope glycoprotein spike, the sole antigen on the Lassa virus (LASV) surface, constitutes the focal point of the host neutralizing immune response. A high-resolution structure of the trimeric LASV glycoprotein in an antibody-bound form illuminates the molecular architecture of the antigen and reveals the mode of action of the most abundant known class of Lassa-specific human neutralizing antibodies.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 78.6KB)
-
- Publisher copy:
- 10.1038/nsmb.3431
-
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Structural and Molecular Biology Journal website
- Volume:
- 24
- Issue:
- 7
- Pages:
- 559-560
- Publication date:
- 2017-07-06
- Acceptance date:
- 2017-06-01
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
- Pubs id:
-
pubs:707583
- URN:
-
uri:c1fa492e-77d0-4a67-8b7b-5ba5aa3a5022
- UUID:
-
uuid:c1fa492e-77d0-4a67-8b7b-5ba5aa3a5022
- Local pid:
- pubs:707583
- Language:
- English
- Subjects:
- Copyright holder:
- Nature America, Inc
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Nature America, Inc., part of Springer Nature. This is the accepted manuscript version of the article. The final version is available online from nature at: https://doi.org/10.1038/nsmb.3431
Journal article
Human antibody pieces together the puzzle of the trimeric Lassa virus surface antigen
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