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A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency

Abstract:

Superparamagnetic iron oxide nanoparticles (SPIONs) have mainly been used as cellular carriers for genes and therapeutic products, while their use in subcellular organelle isolation remains underexploited. We engineered SPIONs targeting distinct subcellular compartments. Dimercaptosuccinic acid-coated SPIONs are internalized and accumulate in late endosomes/lysosomes, while aminolipid-SPIONs reside at the plasma membrane. These features allowed us to establish standardized magnetic isolation ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Authors


Tharkeshwar, AK More by this author
Trekker, J More by this author
Vermeire, W More by this author
Pauwels, J More by this author
Sannerud, R More by this author
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Funding agency for:
Platt, FM
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Grant:
AKUL/09/037, 11/30, 13/39
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Publication date:
2017-01-30
Acceptance date:
2016-12-19
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:668008
URN:
uri:c1f123d3-1269-4037-9672-4a968555c749
UUID:
uuid:c1f123d3-1269-4037-9672-4a968555c749
Local pid:
pubs:668008

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