Evidence for increased in vivo sodium-potassium pump activity and potassium efflux in skeletal muscle of spontaneously hypertensive rats.

Journal article

We have used 87Rb nuclear magnetic resonance spectroscopy (NMR) to study in vivo rubidium kinetics in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) controls, using rubidium as a marker for potassium. We gave 15 male, 13-week-old SHR, mean +/- s.d. blood pressure 180 +/- 10 mmHg, and 15 age-matched normotensive controls, mean blood pressure 120 +/- 9 mmHg, a daily dose of RbCl (2 mmol/kg intraperitoneally). We made repeated NMR measurements of skeletal muscle rubidium concentrat...

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Authors: Syme, P; Dixon, R; Aronson, J; Grahame-Smith, D; Radda, G

• Publication status: Published
• Journal: Journal of hypertension
• Volume: 8
• Issue: 12
• Pages: 1161-1166
• Publication date: 1990-12-01
• DOI: 10.1097/00004872-199012000-00014
• EISSN: 1473-5598
• ISSN: 0263-6352
• Language: English
• Keywords: Rubidium; Sodium-Hydrogen Antiporter; Potassium; Biological Transport, Active; Rats; Hypertension; Muscles; Rats, Inbred WKY; Magnetic Resonance Spectroscopy; Carrier Proteins; Male; Sodium-Potassium-Exchanging ATPase; Sodium; Rats, Inbred SHR; Potassium Channels; Animals