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Journal article

Human leukocyte antigens and natural selection by malaria.

Abstract:

The extraordinary polymorphism of human leukocyte antigens (HLA) poses a question as to how this remarkable diversity arose and is maintained. The explanation that infectious pathogens are largely responsible is theoretically attractive but clear and consistent associations between HLA alleles and major infectious diseases have rarely been identified. Large case-control studies of HLA types in African children with severe malaria indicate that HLA associations with this parasitic infection do...

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Publication status:
Published

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Publisher copy:
10.1098/rstb.1994.0155

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Allsopp, CE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
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Journal:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume:
346
Issue:
1317
Pages:
379-385
Publication date:
1994-11-05
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
URN:
uuid:c1e83814-9d82-4225-b597-8678fd43cf90
Source identifiers:
35669
Local pid:
pubs:35669

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