Journal article icon

Journal article

Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.

Abstract:

Much uncertainty still exists over what T-cell responses need to be induced by an effective human immunodeficiency virus (HIV) vaccine. Previous studies have hypothesized that the effective CD8(+) T-cell responses are those driving the selection of escape mutations that reduce viral fitness and therefore revert post-transmission. In this study, we adopted a novel approach to define better the role of reverting escape mutations in immune control of HIV infection. This analysis of sequences fro...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1128/JVI.00580-08

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
Expand authors...
Journal:
Journal of virology
Volume:
82
Issue:
17
Pages:
8548-8559
Publication date:
2008-09-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:c1e6dd07-0d9f-49bf-a989-67173d26088e
Source identifiers:
191191
Local pid:
pubs:191191

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP