Structural basis of the migfilin-filamin interaction and competition with integrin beta tails.

Journal article

A link between sites of cell adhesion and the cytoskeleton is essential for regulation of cell shape, motility, and signaling. Migfilin is a recently identified adaptor protein that localizes at cell-cell and cell-extracellular matrix adhesion sites, where it is thought to provide a link to the cytoskeleton by interacting with the actin cross-linking protein filamin. Here we have used x-ray crystallography, NMR spectroscopy, and protein-protein interaction studies to investigate the molecular...

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Authors: Lad, Y; Jiang, P; Ruskamo, S; Harburger, D; Ylänne, J

• Journal: Journal of biological chemistry
• Volume: 283
• Issue: 50
• Pages: 35154-35163
• Publication date: 2008-12-01
• DOI: 10.1074/jbc.m802592200
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: Cytoskeleton; Contractile Proteins; Microfilament Proteins; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Animals; Cell Adhesion Molecules; Ligands; Dose-Response Relationship, Drug; Cytoskeletal Proteins; NIH 3T3 Cells; Mice; Humans; Protein Binding; Integrin beta Chains