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The role of DLL4-NOTCH signalling in endothelial cell metabolism

Abstract:

Tumour tissue is characterised by fluctuating oxygen concentrations, decreased nutrient supply, and acidic pH. Angiogenic signalling pathways that drive a certain metabolic 'configuration' may give endothelial cells a selective advantage in the tumour environment. Previously it has been shown that glycolysis drives proliferation, migration and tip cell formation during sprouting of endothelial cells (De Bock, Georgiadou et al. 2013), and is increased by VEGFA. DLL4-NOTCH has been ...

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Institution:
University of Oxford
Research group:
Hypoxia and Angiogenesis Group
Oxford college:
St Hugh's College
Department:
Medical Sciences Division - Medical Oncology

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:c1cf8e8e-5432-4e48-bda1-738455bfbb6d
Local pid:
ora:11373

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