Journal article
Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway.
- Abstract:
-
The co-transmitter neuropeptide Y (NPY), released during prolonged cardiac sympathetic nerve stimulation, can attenuate vagal-induced bradycardia. We tested the hypothesis that NPY reduces acetylcholine release, at similar concentrations to which it attenuates vagal bradycardia, via pre-synaptic Y2 receptors modulating a pathway that is dependent on protein kinase A (PKA) or protein kinase C (PKC). The Y2 receptor was immunofluorescently colocalized with choline acetyl-transferase containing ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.yjmcc.2007.10.001
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Bibliographic Details
- Journal:
- Journal of molecular and cellular cardiology
- Volume:
- 44
- Issue:
- 3
- Pages:
- 477-485
- Publication date:
- 2008-03-01
- DOI:
- EISSN:
-
1095-8584
- ISSN:
-
0022-2828
- Source identifiers:
-
105350
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:105350
- UUID:
-
uuid:c1cf588d-ed3b-473e-b940-a04ff4efc313
- Local pid:
- pubs:105350
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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