Journal article icon

Journal article

Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway.

Abstract:

The co-transmitter neuropeptide Y (NPY), released during prolonged cardiac sympathetic nerve stimulation, can attenuate vagal-induced bradycardia. We tested the hypothesis that NPY reduces acetylcholine release, at similar concentrations to which it attenuates vagal bradycardia, via pre-synaptic Y2 receptors modulating a pathway that is dependent on protein kinase A (PKA) or protein kinase C (PKC). The Y2 receptor was immunofluorescently colocalized with choline acetyl-transferase containing ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.yjmcc.2007.10.001

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
Journal:
Journal of molecular and cellular cardiology
Volume:
44
Issue:
3
Pages:
477-485
Publication date:
2008-03-05
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
URN:
uuid:c1cf588d-ed3b-473e-b940-a04ff4efc313
Source identifiers:
105350
Local pid:
pubs:105350

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP