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Journal article

Sclerosing cholangitis.

Abstract:

Primary sclerosing cholangitis is a chronic cholestatic liver disease of unknown etiology. Immunogenetic factors are considered important in its pathogenesis. The genetic susceptibility to primary sclerosing cholangitis is associated, in part, with the HLA HLA-DRB1, DQA1, DQB1 haplotype. Liver histology in primary sclerosing cholangitis is characterized by a portal inflammatory infiltrate mostly composed of memory T cells. Many patients eventually will develop cholangiocarcinoma, and inactiva...

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Publication status:
Published

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Authors


Martins, EB More by this author
Chapman, RW More by this author
Journal:
Current opinion in gastroenterology
Volume:
16
Issue:
5
Pages:
444-449
Publication date:
2000-09-05
DOI:
EISSN:
1531-7056
ISSN:
0267-1379
URN:
uuid:c1cceebb-27e2-49f5-a67d-97919030321e
Source identifiers:
171693
Local pid:
pubs:171693
Language:
English

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