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Journal article

ASPP: a new family of oncogenes and tumour suppressor genes.

Abstract:

The apoptosis stimulating proteins of p53 (ASPP) family consists of three members, ASPP1, ASPP2 and iASPP. They bind to proteins that are key players in controlling apoptosis (p53, Bcl-2 and RelA/p65) and cell growth (APCL, PP1). So far, the best-known function of the ASPP family members is their ability to regulate the apoptotic function of p53 and its family members, p63 and p73. Biochemical and genetic evidence has shown that ASPP1 and ASPP2 activate, whereas iASPP inhibits, the apoptotic ...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6603525

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Role:
Author
Journal:
British journal of cancer
Volume:
96
Issue:
2
Pages:
196-200
Publication date:
2007-01-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:c1c6d852-5784-4edf-b3c6-0c25bf324b24
Source identifiers:
83990
Local pid:
pubs:83990

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