Journal article
Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8 + T cells
- Abstract:
-
Human mucosal associated invariant T (MAIT) CD8 + and Tc17 cells are important tissue-homing cell populations, characterized by high expression of CD161 ( ++) and type-17 differentiation, but their origins and relationships remain poorly defined. By transcriptional and functional analyses, we demonstrate that a pool of polyclonal, precommitted type-17CD161 ++CD8αβ + T cells exist in cord blood, from which a prominent MAIT cell(TCR Vα7.2 +) population emerges postnatally. During this expansion...
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- Publisher copy:
- 10.1182/blood-2011-05-353789
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Authors
Bibliographic Details
- Journal:
- Blood
- Volume:
- 119
- Issue:
- 2
- Pages:
- 422-433
- Publication date:
- 2012-01-12
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- URN:
-
uuid:c1baf850-c42f-46a7-ac41-ff28525c0530
- Source identifiers:
-
342863
- Local pid:
- pubs:342863
Item Description
- Language:
- English
Terms of use
- Copyright date:
- 2012
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