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Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation.

Abstract:

The Src-homology domain 2 (SH2)-containing cytoplasmic tyrosine phosphatase, SHP-1 (SH2-containing protein tyrosine phosphatase-1), interacts with several B cell surface and intracellular signal transduction molecules through its SH2 domains. Mice with the motheaten and viable motheaten mutations are deficient in SHP-1 and lack most mature B cells. To define the role of SHP-1 in mature B cells, we expressed phosphatase-inactive SHP-1 (C453S) in a mature B cell lymphoma line. SHP-1 (C453S) ret...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
162
Issue:
5
Pages:
2717-2724
Publication date:
1999-03-29
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:c1b631c0-d4dd-4327-8d4f-e8a02098d528
Source identifiers:
483510
Local pid:
pubs:483510

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