Journal article
Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation.
- Abstract:
-
The Src-homology domain 2 (SH2)-containing cytoplasmic tyrosine phosphatase, SHP-1 (SH2-containing protein tyrosine phosphatase-1), interacts with several B cell surface and intracellular signal transduction molecules through its SH2 domains. Mice with the motheaten and viable motheaten mutations are deficient in SHP-1 and lack most mature B cells. To define the role of SHP-1 in mature B cells, we expressed phosphatase-inactive SHP-1 (C453S) in a mature B cell lymphoma line. SHP-1 (C453S) ret...
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Bibliographic Details
- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 162
- Issue:
- 5
- Pages:
- 2717-2724
- Publication date:
- 1999-03-29
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:c1b631c0-d4dd-4327-8d4f-e8a02098d528
- Source identifiers:
-
483510
- Local pid:
- pubs:483510
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 1999
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